An undergraduate laboratory experiment for the synthesis of biologically significant bis-4-hydroxycoumarins using a new catalyst is described here. An experimental setup plan, monitoring the reaction by TLC, isolation of the product, safe laboratory handling procedures, and significance of data reproducibility of the result are the main learning…

Joseph Priestley, discoverer of oxygen, lived in Nantwich, Cheshire, UK, from 1758 to 1761. In 2019, an exhibition featuring his life and achievements, and also celebrating the International Year of the Periodic Table, was developed by the Nantwich Museum. The historical research of Priestley's life, development of the exhibition, and rationale…

This paper demonstrates the use of a smartphone's sensors in recording experimental data for investigating the large angle of a physical pendulum. The smartphone (iPhone 5s) was attached to a beam to record simultaneously both the angular position and the angular speed of the beam oscillating about the pivot. The period and phase space of the…

The Wright brothers, Wilbur and Orville, are often depicted as lone geniuses, secretly assembling the first successful powered aircraft far from civilization at Kitty Hawk on the Outer Banks of North Carolina. There is a germ of truth in the popular story, but only a germ. The brothers succeeded while so many other experimenters failed not because…

Multitouch experiment instructions (MEIs), implemented as interactive eBooks, are learning tools for pupils that offer various digital support tools and enable pupils to individualize their learning. They may be applied to contexts such as inquiry-based experiments in school laboratories, which involve highly demanding cognitive processes and…

Natural scientists are relaxed about the multiple forms experiment takes in their various fields. Yet in education we have for many years constrained our notion of experiment. This methodological circumscription has been self-imposed on the grounds that experiment of a particular, well-defined form offers the clearest evidence of a link between…

Although many laboratory experiments are available to illustrate spectrophotometric or fluorometric methods, few of them introduce the use of luminometry to students. Bioluminescence, a subtype of chemiluminescence, is produced when an enzyme-catalyzed chemical reaction gives rise to light emission. Despite the advantages of bioluminescent…

By building a schlieren optical system, the visualization of a 40 KHz sound wave is realized. By using the schlieren system, the demonstration of acoustic reflection, interference and diffraction can be easily realized. At the same time, the visual acoustic field provides another simple way for the measurement of sound velocity. In this paper, the…

A common procedure when conducting physics experiments is to repeat a measurement several times to calculate the mean and standard deviation. That might be the only instruction we give to students as a means to minimize random errors. However, that technique does not guarantee that the answer will be correct. It might give the same wrong answer…

We have investigated the motion of water flow through glass tubes of different shapes by calculating the value of the Reynolds number denoted as Re. We know that at a given flow rate the value of Re determines the type of flow being classified as laminar, transitional or tubulent. The dependence of Re in different configurations of glass tubes as…

The goal of this laboratory exercise is to give upper-level undergraduate students an introduction to sterile technique in mammalian cell culture and metabolism. The experiment can be completed within a 3-h lab period and can be performed either in conjunction with other biochemistry/metabolism experiments or used as a stand-alone experiment. In…

Kundt's tube is a popular experiment commonly used in schools, in which standing sound waves are made visible inside a glass tube. A fine powder is stirred up in areas of high sound particle velocities, so that one can measure the wavelength of the sound waves by examining the patterns created. In this way, the 'invisible' can be made visible.…

Chemical screening libraries often feature natural product extracts (NPEs) due to the intriguing biological activities they possess and the structural diversity found in their individual components. A research project originally designed to create an extract library of every specimen in the University of Rhode Island (URI) Heber W. Youngken Jr.…

Understanding the abstract principles of statistical experimental design can challenge undergraduate students, especially when learned in a lecture setting. This article presents a concrete and easily replicated example of experimental design principles in action through a hands-on learning activity for students enrolled in an experimental design…

X-ray crystallography provides structural information of molecules at the atomic level, being a central technique at the forefront of science and technology. However, crystallography teaching is not usually implemented in biochemistry lab classes due to its complex execution by nonexpert users. Here, we report the basic step-by-step workflow…