It is known from studies outside the brain that upon binding to its receptor, angiotensin-(1-7) elicits the release of prostanoids and nitric oxide (NO). Cyclooxygenase (COX) is a key enzyme that converts arachidonic acid to prostaglandins. Since there are no data available so far on the role of COX-2 in the amygdala, in a first step we…

The human brain is not a passive organ simply waiting to be activated by external stimuli. Instead, we propose that the brain continuously employs memory of past experiences to interpret sensory information and predict the immediately relevant future. The basic elements of this proposal include analogical mapping, associative representations and…

To speak of cognitive regulation versus emotion regulation may be misleading. However, some forms of regulation are carried out by executive processes, subject to voluntary control, while others are carried out by "automatic" processes that are far more primitive. Both sets of processes are in constant interaction, and that interaction gives rise…

Participants report briefly-presented words more accurately when two copies are presented, one in the left visual field (LVF) and another in the right visual field (RVF), than when only a single copy is presented. This effect is known as the "redundant bilateral advantage" and has been interpreted as evidence for interhemispheric cooperation. We…

This study explored the impact of infant-directed speech (IDS) versus adult-directed speech (ADS) on neural activity to familiar and unfamiliar words in 6- and 13-month-old infants. Event-related potentials were recorded while infants listened to familiar words in IDS, familiar words in ADS, unfamiliar words in IDS, and unfamiliar words in ADS.…

Under what conditions can a true "science of mental life" arise from psychological investigations? Can psychology formulate scientific laws of a general nature, comparable in soundness to the laws of physics? I argue that the search for such laws must return to the forefront of psychological and developmental research, an enterprise that requires…

A biologically detailed computational model is described of how categorization judgments become automatic in tasks that depend on procedural learning. The model assumes 2 neural pathways from sensory association cortex to the premotor area that mediates response selection. A longer and slower path projects to the premotor area via the striatum,…

This paper considers mathematical abstraction as arising through a natural mechanism of the biological brain in which complicated phenomena are compressed into thinkable concepts. The neurons in the brain continually fire in parallel and the brain copes with the saturation of information by the simple expedient of suppressing irrelevant data and…

Recent data suggest that subthreshold presentation of emotional information is relayed to the amygdala along subcortical pathways. We examined the effect of backward masked neutral and anxious faces on the social decisions of a group of high functioning children with autism ages 7-13 years and matched controls. Participants were asked to select…

Until recently, the dominant view was that schizophrenia patients have limited, if any, neuropsychological impairments, and those that are observed are only secondary to the florid symptoms of the disorder. This view has dramatically changed. This review integrates recent evidence demonstrating the severity and profile of neuropsychological…

In this article, the author presents a discussion regarding the sharing of decision making regarding curriculum in preschool. The preschool where she teaches is housed in a diverse, faith-based elementary school in the heart of Grand Rapids, Michigan, a midsize, midwestern city. It offers full-day, half-day, and two-and-a-half-hour preschool…

Hemisphere-specific processing of laterally presented global and local stimulus levels was investigated by (a) examining interactions between the visual field of stimulus presentation and the response hand and (b) comparing intra- with inter-hemispheric effects of level priming (i.e. faster and more accurate performance when the target level…

Toxic exposures during pregnancy and early childhood continue to play an important role as a preventable cause of neurodevelopmental disabilities in the U.S. and around the world. Identifying and eliminating these toxins should be a priority, but the task is made exceedingly difficult due to the severe limits of scientific knowledge in this area…

A review of research makes it increasingly clear that findings from the areas of brain development and hemispheric specialization, student and teacher learning styles, and holistic and meaning-centered approaches to reading and writing are related, as they all contribute to a richer view of how learners learn. In brain research, the popular focus…

Fragile X syndrome (FXS), caused by a single gene mutation on the X chromosome, offers a unique opportunity for investigation of gene-brain-behavior relationships. Recent advances in molecular genetics, human brain imaging, and behavioral studies have started to unravel the complex pathways leading to the cognitive, psychiatric, and physical…