Background: A broad capacity for deliberate self-regulation plays a key role in emotion regulation. This longitudinal investigation from infancy to preschool age examines genotype by environment (G x E) interaction in the development of self-regulation, using molecular measures of children's genotypes and observed measures of the quality of early…

Background: Standardised neuropsychological and cognitive measures present some limitations in their applicability and generalisability to individuals with intellectual disability (ID). Alternative approaches to defining the cognitive signatures of various forms of ID are needed to advance our understanding of the profiles of strengths and…

Definitions of biosphere and ecosystem are provided as the basis for understanding a problem that threatens to become (or already is) a global issue, namely, human activity which results in reducing the diversity of life forms present in the biosphere as an ecosystem. Two aspects of this problem are: (1) the growth of human populations worldwide…

These proceedings of a symposium designed to increase public awareness of current research in biology and biotechnology include: welcoming addresses by Chau Sian Eng and S. Radhakrishna; an opening address by Tay Eng Soon; five papers; four abstracts; summary; symposium program; and list of participants. The five papers are: (1) "The Role of…

The biotechnology revolution is making contributions to the improvement of health care. Some of the biotechnology-based pharmaceuticals in the marketplace include human hormones, enzymes, enzyme inhibitors, vaccines, immunomodulators, growth factors, and monoclonal antibodies. Many new diagnostics will appear and be used by patients in their own…

Presents a protocol that can be used to discover that S. marcescens produces a bright red pigment when exposed to one temperature condition and does not produce this color under other conditions. Enables students to connect gene expression and environmental changes. (DDR)

Recent changes in genetics research have created new opportunities to improve the scope and quality of newborn screening services. Changes in newborn screening should be supported and directed by an organized program of research. The NICHD Research Initiative in Newborn Screening includes the development of systematic methods to identify…

Since the identification of the FMR1 gene basic research has been focused on the molecular characterization of the FMR1 gene product, the fragile X mental retardation protein (FMRP). Recent developments in fragile X research have provided new insights and knowledge about the physiological function of FMRP in the cell and the nerve cell in…

Fragile X syndrome is the most common heritable form of mental retardation caused by loss-of-function mutations in the "FMR1" gene. The "FMR1" gene encodes an RNA-binding protein that associates with translating ribosomes and acts as a negative translational regulator. Recent work in "Drosophila melanogaster" has shown that the fly homolog of…

Proposes models for the evolution of the genetic code and translation mechanisms. Suggests that the translation process is so complex and precise that it must have evolved in many stages, and that the evolution of the code was influenced by the constraints imposed by the evolving translation mechanism. (EB)

Addresses issues related to genetic counseling and deafness. (Author/VWL)

Discusses genetics and its relevance to the lives of deaf people. Examines how the advances in genetics technologies have led to greater knowledge regarding the genetic causes of deafness and how this impacts the deaf community. (Author/VWL)

In the present study we confirm the previously reported high frequency of biochemical markers of mitochondrial dysfunction, namely hyperlactacidemia and increased lactate/pyruvate ratio, in a significant fraction of 210 autistic patients. We further examine the involvement of the mitochondrial aspartate/glutamate carrier gene ("SLC25A12") in…

This article undertakes a close rhetorical reading of the speeches given by Bill Clinton, Tony Blair, Francis Collins, and Craig Venter on June 26, 2000, at the White House ceremony announcing the completion of the Human Genome Project. Specifically, it looks at the metaphors used by each speaker to describe the activity of genomic scientists.…