The reliability of cognitive demand measures in controlled laboratory settings is well-documented; however, limited research has directly established their stability under real-life and high-stakes conditions, such as operating automated technology on actual highways. Partially automated vehicles have advanced to become an everyday mode of…

The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1[alpha] levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4-12 years were included. Serum levels of VEGF, IGF-1, and HIF-1[alpha] were measured using commercial enzyme-linked…

Genetic, neurobiological, neurochemical, environmental factors and their interactions contribute to autism phenotypes. Blood from 48 (age range: 4-17) autism spectrum disorder diagnosed patients (ASD) and 38 age- and gender-matched healthy control subjects was analyzed for numbers of neutrophils, lymphocytes, monocytes, albumin, serum…

This dissertation is in two parts: Part 1 of the study focuses on investigating the feasibility of delivering turn-on rhodamine-based fluorophores through Glucose transporters (GLUTs) for biomedical applications, both "in vitro" and in vivo. Fluorescent GLUT targeting probes are essential for analyzing transport activity, monitoring…

Math anxiety and academic distress, two interrelated forms of psychological stress, are pervasive problems for undergraduate mathematics students. Most of the research in this area has taken a broad view of the impact this stress has on students' learning across an entire course or, more broadly, the entire curriculum for their degree. To…

Sleep problems are prevalent in autism spectrum disorder (ASD) and have a range of causes, including circadian rhythm misalignment. However, little is known about sleep in autistic children with co-occurring attention deficit hyperactivity disorder (ADHD). A cross-sectional descriptive and analytic study was conducted in 87 autistic children and…

Metabolism is always a challenging topic in biochemistry. In our project, a courseware called "Metabolism Metro" was developed. "Metabolism Metro" is a self-learning tool which aims to facilitate students learning of metabolic pathways in an interactive and easy-to-understand manner. The courseware includes both pre-class and…

Background: Student perceptions of teachers' interpersonal closeness positively affect their emotions. If closeness is, however, effortful for the teacher (i.e., emotional labour, signalling less genuine closeness), this may undermine these positive effects. We tested this assumption by using student reports and external observations of teacher…

This paper focuses on the physiological identification of Clutch-Flow states in real-world educational scenarios. By using the Eduflow scale and Polar H10 wearable devices, we develop two STEAM face-to-face project-base teaching-learning experiences with students in 5th and 6th grade of primary education. Based on Heart Rate Variation (HRV)…

Although research demonstrates benefits of collaboration in problem-solving, less is known about how different formats impact learning and cognitive engagement. This study compared in-person and virtual collaboration to individual problem-solving by measuring performance and cognitive engagement, using heart rate variability (HRV). Participants…

For STEM faculty to approach teaching as a scientist, they must develop tools for data collection and analysis of student learning outcomes. Here, we report a methodology for the development of a learning outcomes assessment instrument and statistical analysis of that instrument that can be undertaken in a short amount of time by a few faculty…

Learning and dissemination of obesity physiology and etiology knowledge are essential to prevention and treatment of this chronic disease through concerted efforts from both professionals and the general public. In this article, we describe an innovative Gain in Research Ability Test per Literature (GRATL) framework that integrates artificial…

The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was…

Purpose: This study aimed to examine the activities of heart rate variability (HRV) and cortisol secretion as markers of the autonomous nervous system (ANS) and the hypothalamic-pituitary-adrenal axis (HPA) during the menstrual cycle in female athletes. Method: Saliva samples of the participants (n = 28) were collected successively at 0, 15, 30,…

Purpose: The biological mechanisms underlying developmental stuttering remain unclear. In a previous investigation, we showed that there is significant spatial correspondence between regional gray matter structural anomalies and the expression of genes linked to energy metabolism. In the current study, we sought to further examine the relationship…