We are in a rapidly evolving landscape where knowledge and information are catalysts for innovation and economic growth. However, the current Library and Information Science (LIS) curriculum has failed to equip graduates with the requisite 21st-century skills needed for innovation and self-reliance, thereby exacerbating unemployment challenges, especially in a developing nation like Nigeria. Hence, this paper highlights the critical need to instil infopreneurial content into the LIS curriculum of Nigeria, to foster creativity among the LIS students by making them identify and capitalize on information-based opportunities. In the process, an overview of 21st-century librarianship was made, Nigeria as a developing nation was discussed, the meaning and areas of infopreneurship practice were highlighted, obstacles to infopreneurial practice in developing nations were explained, and the need for increased involvement of LIS professionals in infopreneurial endeavours to enhance national development are explored. However, the paper proposed curriculum development in the LIS field, to drive innovation and concludes by emphasizing the imperative of embedding infopreneurship content into the LIS curricula as a means of advancing the employment avenues of LIS graduates in emerging nations. [For the complete proceedings, see ED672804.]