The purpose of the current study is to design, implement and evaluate a pedagogical model for skill training integrated with entrepreneurship for sustainability. In this regard, the nature of sustainability, entrepreneurship and integrated skill training, as well as the models of sustainability and entrepreneurship training developed in the literature were first examined. Then, the proposed model was defined as the "Skills Training Integrated with Entrepreneurship for Sustainability" model. The study group consists of fourth-year pre-service science teachers. The study, conducted using the design-based research method, consists of three stages: "exploration, design and implementation." Through these stages, a document analysis, the design of the model and the training framework aligned with the model and a pilot study were carried out, respectively. Thematic, descriptive and content analyses were used to analyze the qualitative data collected through the document analysis and interview forms. The model designed in the study defines the competency areas required for integrated skill training for sustainability to be used in the undergraduate education of pre-service science teachers, while the developed training framework demonstrates learning-teaching practices compatible with these competency areas. In this context, the study is considered to be important for the literature on science education and sustainability. It is recommended that the training model designed in the study can be used as a moderator variable in the preparation and evaluation of green entrepreneurship activities related to sustainability issues, in determining instructors' pedagogical competencies and in observing their development over time.