Autistic adults have reported experiencing discrimination across settings. Nonetheless, population-based research examining the prevalence of discrimination against autistic individuals has been more limited. Therefore, this study aimed to examine the prevalence of types of discrimination (i.e., due to race or ethnicity, due to sexual orientation or gender identity, and due to health condition or disability) experienced by autistic youth (n = 2339) compared to youth with other neurodevelopmental diagnoses (i.e. attention-deficit/hyperactivity disorder, learning disability, and speech or other language disorder; n = 10,325) and neurotypical youth (n = 44,781) 6-17 years of age utilizing a large, population-based sample. Data for this study were acquired from the 2021-2022 National Survey of Children's Health, a nationally distributed caregiver-report questionnaire. Results found that the prevalence of discrimination due to race or ethnicity and sexual orientation or gender identity was higher among autistic youth than neurotypical youth. Notably, results also found that discrimination due to health condition or disability was far more prevalent among autistic youth than neurotypical youth and youth with other neurodevelopmental diagnoses. Findings highlight the increased prevalence of discrimination experienced by autistic youth and should prompt researchers, policymakers, and vested community members to action to address this problem.