A reference interval, or an interval in which a prespecified proportion of measurements from a healthy population are expected to fall, is used to determine whether a person's measurement is typical of a healthy individual. For a specific biomarker, multiple published studies may provide data collected from healthy participants. A reference…

E-texts afford interactive features that are not feasible with paper texts. Several studies have been conducted examining interactive features of E-texts, but it is uncertain what the overall effect is or what features may be most useful. The purpose of this study is to systematically review and meta-analysis of the findings comparing reading…

In meta-analyses of rare events, it can be challenging to obtain a reliable estimate of the pooled effect, in particular when the meta-analysis is based on a small number of studies. Recent simulation studies have shown that the beta-binomial model is a promising candidate in this situation, but have thus far only investigated its performance in a…

Single-case designs (SCDs) are a class of research methods for evaluating the effects of academic and behavioral interventions in educational and clinical settings. Although visual analysis is typically the first and main method for primary analysis of data from SCDs, quantitative methods are useful for synthesizing results and drawing systematic…

The four-component instructional design model (4C/ID) has been increasingly used in face-to-face and online learning environments. We present a meta-analysis on the use and effect on performance of educational programs developed with the 4C/ID model after more than 20 years of its application and research in different academic areas and technical…

Publishing systematic review protocols is a fundamental part of systematic reviews to ensure transparency and reproducibility. In this scoping review, we aimed to evaluate reporting of Cochrane systematic review protocols with network meta-analyses (NMA). We searched all Cochrane NMA protocols published in 2018 and 2019, and assessed the…

Multiple 'overviews of reviews' conducted on the same topic ("overlapping overviews") represent a waste of research resources and can confuse clinicians making decisions amongst competing treatments. We aimed to assess the frequency and characteristics of overlapping overviews. MEDLINE, Epistemonikos and Cochrane Database of Systematic…

To present time-varying evidence, cumulative meta-analysis (CMA) updates results of previous meta-analyses to incorporate new study results. We investigate the properties of CMA, suggest possible improvements and provide the first in-depth simulation study of the use of CMA and CUSUM methods for detection of temporal trends in random-effects…

To enable optimal decision-making based on the best evidence available, open syntheses are called for. To make data accessible and comprehensible even for decision-makers without proficient knowledge in meta-analysis, a graphical user interface (GUI) provides flexible data visualizations including interpretation aids. Moreover, due to a growing…

Research on academic performance in online education proliferated in the last decade; however, our current understanding of the relationship between self-regulated learning and academic performance in online learning environments remains scattered. This meta-analysis provides a holistic view of the relationship between learners' use of…

Substantial research has explored the connection between children's spontaneous focusing on numerosity (SFON) and their current and later mathematical achievement. However, the findings have been inconsistent, and no comprehensive investigation has yet been conducted. This meta-analysis examines the relation between SFON and mathematics…

Rapid automatized naming (RAN) has surged in popularity recently as an important indicator of reading difficulties, including dyslexia. Despite an extensive history of research on RAN, including recent meta-analyses indicating a unique contribution of RAN to reading above and beyond phonemic awareness, questions remain regarding RAN's relationship…

Effective learning design (LD) grounded in sound pedagogy is a critical driver of student success. Therefore, it is important to explore how LD of online learning environments influences student ability to manage their own learning. This understanding can inform the development of online programs that prioritize student-driven learning. Research…

Introduction: Bullying and cyberbullying undermine the identity of the young people who suffer them. This multidimensional phenomenon takes place within the peer group, in different interaction settings, outside the classroom contexts. It also presents various risk factors related to leisure spaces and activities, which in many cases have a high…

Students involve themselves in learning activities multidimensionally, including behaviorally, cognitively, emotionally, and agentically. This multidimensional involvement predicts important outcomes, but it is also possible that each type of engagement might have its own specialized purpose or function. To investigate this possibility, we…