Background: The purpose of this study was to increase the body of knowledge regarding the workplace discrimination experiences of individuals with disabilities residing in the Pacific and Northwest (PNW) regions by exploring their allegations filed under Title I of the Americans with Disabilities Act (ADA). Objective: The goals of this article are to describe region- and state-level patterns in workplace discrimination and to provide valuable information to stakeholders to better understand and address job discrimination within their respective areas of practice. Methods: The Integrated Mission System database documents every available closed allegation of job discrimination under the ADA. Data for each state include overall frequencies and proportions. Data are presented as respective national and regional rankings for comparison purposes. Descriptive and nonparametric statistics were obtained for each of the five specific research questions. Findings: Variables selected for study include the frequency of allegations, the impairment of the charging party, alternative prongs of the ADA definition of disability, the nature of the unlawful discrimination alleged (known as issues), and the outcome of the EEOC investigation (known as merit or nonmerit). These are presented in tables for ease of comparison. Finally, the next steps in research and other possibilities for knowledge translation are discussed. Conclusion: The findings suggest that workplace discrimination against individuals with disabilities varies significantly by state in the PNW, highlighting the need for tailored interventions at the state level. Differences in support services, advocacy, and public awareness about ADA protections contribute to these disparities. Future efforts should focus on enhancing ADA literacy and targeted interventions to address state-specific issues in reducing discrimination in the workplace.