Background: Autism typically begins in childhood and affects over five million adults across the United States. Although most adults with autism would like to work, only about one-fourth are employed, and only 1% of working-age adults with autism receive employment services paid for by Vocational Rehabilitation or Medicaid. Individual Placement and Support (IPS) is an evidence-based supported employment program developed for people with mental health disabilities that has been extended to new populations, including adults with autism. This project explored the perspectives of IPS employment specialists and other professionals who have worked with adults with autism. Objective: This project explored the perspectives of IPS employment specialists and other professionals who have worked with adults with autism. Methods: This project used semistructured qualitative interviews with experienced professionals to explore their experiences delivering IPS to adults with autism. Findings: Interviews with 35 professionals from seven U.S. states and two European countries yielded two themes: strategies to work with adults with autism and programmatic considerations. Participants recommended no major changes to the core principles of IPS but suggested minor adjustments, such as providing increased support for social interactions on the job and working closely with families and employers. Conclusions: Although no major adaptations to IPS were reported, improving training, addressing structural barriers, and centering the voices of adults with autism are key to enhancing employment outcomes and guiding future research.