The integration of semantic information of compound words with context is a crucial aspect of reading comprehension. In two eye-tracking experiments, we used two-character and four-character Chinese lexicalized and novel compound words to investigate how Chinese readers integrate semantic information of compound words with contexts in the present study. By manipulating the temporary plausibility of the first constituent through varying the preceding verb, we aimed to investigate how readers process semantic information of compound words during normal reading. A significant plausibility effect pattern in the first constituent region was observed for the four-character novel words, but not for the lexicalized compound words and two-character novel compound words. However, for both two-character and four-character novel compound words, a reverse plausibility effect was found in the second constituent region. This was not the case for lexicalized compound words. These results indicate that novel compound words are integrated with the context in a decompositional manner, while lexicalized compound words are integrated holistically.