Objective: The functioning of neural systems supporting emotion processing and regulation in youth with bipolar disorder not otherwise specified (BP-NOS) remains poorly understood. We sought to examine patterns of activity and connectivity in youth with BP-NOS relative to youth with bipolar disorder type I (BP-I) and healthy controls (HC). Method:…

In the first installment of this series (Exceptional Parent Magazine, May 2010), the author discussed epilepsy surgery performed in persons whose areas of brain abnormality were initially deemed to be too extensive to safely perform a resection of the involved area. The process leading to surgical remediation for seizures is an involved one, but…

Recent work suggests that a dose of 200-400mg caffeine can enhance both vigilance and the executive control of visual attention in individuals with low caffeine consumption profiles. The present study seeks to determine whether individuals with relatively high caffeine consumption profiles would show similar advantages. To this end, we examined…

The perception and processing of temporal information are tasks the brain must continuously perform. These include measuring the duration of stimuli, storing duration information in memory, recalling such memories, and comparing two durations. How the brain accomplishes these tasks, however, is still open for debate. The temporal bisection task,…

Little is known about the neuropsychological factors that contribute to individual differences in the asymmetric orientation along the mental number line. The present study documents healthy subjects' preference for small numbers over large numbers in a random number generation task. This preference, referred to as "small-number bias" (SNB),…

The ability to represent desires and intentions as two distinct mental states was investigated in patients with parietal (N = 8) and frontal (N = 6) lesions and in age-matched controls (N = 7). A task was used where the satisfaction of the desire and the fulfilment of the intention did not co-vary and were manipulated in a 2 x 2 set. In two…

Neuroscience has greatly improved our understanding of the brain basis of abstract lexical and semantic processes. The neuronal devices underlying words and concepts are distributed neuronal assemblies reaching into sensory and motor systems of the cortex and, at the cognitive level, information binding in such widely dispersed circuits is…

We took snapshots of human brain activity with fMRI during retrieval of realistic episodic memory over several months. Three groups of participants were scanned during a memory test either hours, weeks, or months after viewing a documentary movie. High recognition accuracy after hours decreased after weeks and remained at similar levels after…

The study examined whether exercise offered to sedentary, overweight children ages 7 to 11 improved executive function--defined as strategy execution when presented with a novel task--and academic performance in reading and math. The study authors analyzed data on about 170 students from Georgia who were recruited in five cohorts from 2003 to…

Whereas most previous studies on emotion in language have focussed on single words, we investigated the influence of the emotional valence of a word on the syntactic and semantic processes unfolding during sentence comprehension, by means of event-related brain potentials (ERP). Experiment 1 assessed how positive, negative, and neutral adjectives…

Efficient reading relies on expertise in the visual word form area, with abnormalities in the functional specialization of this area observed in individuals with developmental dyslexia. We have investigated event related potentials in print tuning in adults with dyslexia, based on their N170 response at 135-255 ms. Control and dyslexic adults…

This study used fMRI to measure brain activity during adult processing of cries of infants with autistic disorder (AD) compared to cries of typically developing (TD) infants. Using whole brain analysis, we found that cries of infants with AD compared to those of TD infants elicited enhanced activity in brain regions associated with verbal and…

Attention-deficit/hyperactivity disorder (ADHD) is a common developmental disorder often associated with other developmental disorders including speech, language, and reading disorders. Here, we review the principal features of ADHD and current diagnostic standards for the disorder. We outline the ADHD subtypes, which are based upon the dimensions…

Cortical regions supporting cognitive control and memory judgment are structurally immature in adolescents. Here we studied adolescents (13-15 y.o.) and young adults (20-22 y.o.) using a recognition memory paradigm that modulates cognitive control demands through cues that probabilistically forecast memory probe status. Behaviorally, adolescence…

We propose a neural dynamic model that specifies how low-level visual processes can be integrated with higher level cognition to achieve flexible spatial language behaviors. This model uses real-word visual input that is linked to relational spatial descriptions through a neural mechanism for reference frame transformations. We demonstrate that…