Characterization of the vapor pressure of a volatile liquid or azeotropic mixture, and its fluid phase diagram, can be achieved with an isoteniscope and an industrial grade digital pressure sensor using the experimental method reported in this study. We describe vapor-pressure measurements of acetone and n-hexane and their azeotrope, and how the…

This paper presents a successful, free inquiry experiment in which students devise an experiment to measure carbon dioxide in an important chemical, biological, or environmental situation. Also discussed is rationale for adopting an open inquiry experiment and how it fits into the laboratory as a whole. Typical student projects are given, and data…

The synthesis of 1,1-diphenylethylene (DPE) via a Grignard reaction, followed by an acid-catalyzed dehydration reaction, yields a mixture of compounds. DPE is a high boiling liquid that cannot be purified using simple distillation. However, it is easily separated from the more polar starting material and intermediate alcohol using both thin layer…

Analyzing protein structure has become an integral aspect of understanding systems of biochemical import. The laboratory experiment endeavors to introduce protein folding to ascertain structures of proteins for which the structure is unavailable, as well as to critically evaluate the quality of the prediction obtained. The model system used is the…

This work describes a 10-week laboratory project studying wild-type and mutant bacterial alkaline phosphatase, in which students purify, quantitate, and perform kinetic assays on wild-type and selected mutants of the enzyme. Students also perform plasmid DNA purification, digestion, and gel analysis. In addition to simply learning important…

In this experiment for an upper-division course in organic structure determination, each student prepares an unknown compound and characterizes the product using multiple spectroscopic techniques. The unknowns, 2-aryl-substituted 1,4-dihydro-3,1-benzoxazines and 1,2,3,4-tetrahydroquinazolines, are prepared in a single step by the condensation of…

The dramatic decrease in the cost of sequencing a human genome is leading to an era in which a wide range of students will benefit from having an understanding of human genetic variation. Since over 90% of sequence variation between humans is in the form of single nucleotide polymorphisms (SNPs), a laboratory exercise has been devised in order to…

The objective of this paper is to present a laboratory experiment that explains the phenomenon of sinking in quicksand simulated as a fluidized bed. The paper demonstrates experimentally and theoretically that the proportion of a body that sinks in quicksand depends on the volume fraction of solids and the density of the body relative to the…

We described a simple method for detection of Fe on a thread-based analytical device. Fe reacts with 1,10-phenanthroline to form a colored band on a cotton thread; the length was measured to quantify the contents of Fe using a ruler. This method has the advantages of easy operation, low cost, easy fabrication, and reduced sample/reagent…

We present our experience with an open-ended lab activity that we designed for students with a Calculus 1 background. With the goal of learning how scientists study transport in streams, the students collected data on how a pulse of leaves travels down a nearby stream. Students who had little to no experience with data with two independent…

Undergraduate research is a valuable tool to demonstrate both the dedication and time required to be a successful biologist. One area of research that has intrigued students over the last several years is cytotoxicity. However, at smaller undergraduate institutions, the time, training, and funding available for these research studies may be…

While computer simulations are a key element in understanding and doing science today, their nature and implications for science education have not been adequately explored in the relevant literature. In this article, (1) we provide an analysis of the methodology and epistemology of computer simulations, aiming to contribute to a sound and…

Teaching methodologies for the anatomy of the middle ear have not been investigated greatly due to the middle ear's highly complex structure and hidden location inside of the temporal bone. The aim of this randomized study was to quantitatively compare the suitability of using microscope- and endoscope-based methods for teaching the anatomy of the…

The laboratory exercise described here aims to provide a relevant context for learning basic DNA techniques in an introductory animal science course at tertiary level. In two 4-hr laboratory sessions, students assess the suitability of bulls for inclusion in a gene-assisted selection program for A2 [beta]-casein by genotyping commercial bull…

The introduction of the Wireless Smart Cart by PASCO scientific in April 2016 has ushered in a paradigm shift in the design and implementation of low-cost undergraduate physics and engineering laboratory experiments. The use of smartphones in experimental physics is by now widely accepted and documented. The smart cart in combination with…