Amazon Mechanical Turk (MTurk) is a crowdsourcing website that has become a popular participant recruitment tool in social science research. MTurk provides access to a large, diverse, and inexpensive pool of willing participants, and the unique clinical characteristics of MTurk participants may be of particular interest to rehabilitation researchers. In this article, the authors provide a step-by-step guide to set up and conduct a Qualtrics online survey study via MTurk. Several considerations including quality control of data, cost reduction, and ethical considerations are discussed, and strategies to improve data quality and promote research ethics are provided.