Objective: To examine international student-athletes' (ISAs) rates of depression, perceived stress, problematic drinking, and sleep disturbance. Participants: 509 ISAs (M[subscript age] = 20.39 years, women = 63.1%) from over 80 NCAA institutions. Methods: Survey data were collected in April/May 2020. Results: Overall, 27.9% and 9.2% endorsed clinical and high levels of depression and stress, respectively; 2.4% (n = 12) reported severe sleep disturbances and 12.4% (n = 63) problematic drinking. Except problematic drinking, being a woman ISA was associated with significantly higher levels of disturbance. Year in school interacted with gender for perceived stress; men ISAs in their 2nd year or higher reported the lowest levels. Conclusions: Large numbers of ISAs endorsed clinical/severe levels of psychological concerns at onset of COVID-19, likely due to the unique stressors experienced by this international college population. Athletic departments, like universities in general, must provide culturally-sensitive mental health services for their ISAs.