Background: Adults with Down syndrome have demonstrated lower rates of community participation, which is known to reflect a poorer quality of life. This cross-sectional study used survey data completed by 27 care partners of adults with Down syndrome to understand if lower community participation was associated with a recent decreased independence in activities of daily living. Method: Decreased independence in activities of daily living were examined using the NTG-Early Detection Screen for Dementia. The frequency of participation was reported using the Guernsey Community Participation and Leisure Assessment. Results: All changes in activities of daily living showed statistically significant associations with lower participation. Decreased independence in dressing was most strongly associated with a lower frequency of visiting museums ([rho]=-0.533, p = 0.006). Conclusions: Decreased independence in activities of daily living may be useful clinical indicators of lower community participation.