Comprehensive Sexuality Education (CSE) is a curriculum-based process of teaching and learning where learners are equipped with knowledge to cope with their developmental changes and risky sexual behaviors. Teaching and learning sexuality education has been seen as the responsibility for teachers only, however research indicate that it is a responsibility and collaboration of all stakeholders. Underpinned by an Asset-based approach as the theoretical framework this study addressed this question: "How can an Asset-based approach be utilized to enhance Comprehensive Sexuality Education in rural ecologies?" A case study research design and an interpretive research as the paradigm were adopted. Data were generated using focus group discussions, one-on-one interviews and reflective narratives with teachers, parents, learners, pastor, chief, nurse, social worker and a local business representative and analyzed using thematic analysis. The findings pointed out that, the collaboration of various stakeholders enhance the teaching of sexuality education; a strong ongoing partnership between the community and the school should be maintained and sexuality education workshops for young people in collaboration with communities facilitated by social workers. The study concludes that the teaching of Comprehensive Sexuality Education is not a responsibility for schools only, but encourages community-based collaborations and shared activities from the school communities.