E-cigarettes are a popular type of nicotine product among youth in the United States. Hispanic youth, one of the fastest growing populations in the United States, are second only to white youth for e-cigarette use. Analysis of the Parents' Resource Institute for Drug Education data was conducted to determine past 30-day e-cigarette use among Hispanic youth (n = 4,602) and also examined school factors related to such use. Findings indicated that 13.8% of Hispanic youth used e-cigarettes in the past 30 days. Multivariate logistic regression analysis determined several school factors (e.g., poor grades, grade level) related to e-cigarette use. School-based prevention programs are needed to reduce and eliminate e-cigarette use among Hispanic youth.