In recent years, microarray analysis has become a key experimental tool, enabling the analysis of genome-wide patterns of gene expression. This review approaches the microarray revolution with a focus upon four topics: 1) the early development of this technology and its application to cancer diagnostics; 2) a primer of microarray research,…

Today it is widely recognized that a uniform global intellectual property (IP) system requiring a high level of protection is inherently unjust and affects countries differently depending upon their level of technological and economic development. This article analyzes the functioning of the current international treaty framework having…

We report four patients with the syndrome of cerebellar ataxia with bilateral vestibulopathy (CABV) and, using search coil oculography, we validate its characteristic clinical sign, namely impairment of the visually enhanced vestibulo-ocular reflex (VVOR) or doll's head reflex. In our four patients, CABV began in the sixth decade of life; they are…

It seems hard to believe that Dolly the cloned sheep was born 10 years ago, kindling furious arguments over the prospects and ethics of cloning a human. Today, the controversy over cloning is entwined, often confused, with concerns over the use of human embryonic stem cells. Most people are unclear what cloning is, and they know even less when it…

This report provides an overview of Minnesota's Medical Education and Research Costs (MERC) project, which was undertaken to gather data on the costs of medical education and health care research conducted by hospitals, medical centers, and health maintenance organizations and to develop mechanisms to assess the costs across the health care…

As the second phase of a larger investigation, this study sought detailed information about the post-doctoral research training experiences of the faculty in departments of internal medicine and about the relationships between their research training experience and subsequent research activity. A six-page survey form was sent to 7,947 full-time…

Raising a child with a disability requires an even greater amount of information than that needed to raise a "typical" child. This information is not as easily accessed as information regarding typically developing children. Parents require this information to help promote their child's development, learn information about diagnoses and treatment…

Lists issues in planning primary care education, e.g. fear of dilution of excellence, competition for resources, delivery of care, the teaching objective, M.D. and new health professional, benefit and service structure, financial structure, physical and administrative locus, marketing. Emphasis is on coordination of educational research, and…

Alerts science teachers to ethical and social issues as well as research findings associated with recent developments in biomedicine. Also provides a brief list of suggested readings on bioethical issues. (PEB)

In 1988, Harvard University unveiled plans for Medical Science Partners (MSP), a venture capital fund intended to invest in and commercialize faculty biomedical projects. Critical of what is perceived as a "15 year long trend" wherein Harvard has "forged deeper and more extensive ties with the biomedical industry," the document…

Developmental models currently used by child behavioral toxicologists and teratologists are inadequate to address current issues in these fields. Both child behavioral teratology and toxicology scientifically study the impact of exposure to toxic agents on behavior development: teratology focuses on prenatal exposure and postnatal behavior…

Perspectives, policy issues, and options for Congressional action that relate most directly to the development and implementation of alternatives to animal use in research and testing are addressed in this report. Testimonies and reports include those from the Office of Technology Assessment, the National Institute of Health, and the Food and Drug…

This course syllabus for a continuing education course for health science librarians introduces the MEDLARS system, the MEDLINE database, and the Index Medicus. Designed to enable health science librarians to discriminate between the capabilities of manual searching and online retrieval, an overview is given of the nature and scope of MEDLINE and…

Evidence today indicates that the causes of mental retardation are biological, psychological, and social in origin and that a combination of these causes frequently occur in a single individual. Mental retardation is identified clinically by the presence of several signs that include, but are not limited to, a significant impairment of…