This research aimed to comprehensively explore psychopathology in Williams syndrome (WS) across the life span and evaluate the relationship between psychopathology and age category (child or adult), gender, and cognitive ability. The parents of 50 participants with WS, ages 6-50 years, were interviewed using the Schedule for Affective Disorders…

Objective: The goal of the present study is to test whether there are Attention-Deficit Hyperactivity Disorder (ADHD)-related differences in brain electrical activity patterns across arousal, activation and vigilance states. Method: The sample consists of 80 adults (38 with ADHD and 42 non-ADHD controls) who were recruited for a family study on…

Background: Studies into the phenotype of rare genetic syndromes largely rely on bivariate analysis. The aim of this study was to describe the phenotype of Cornelia de Lange syndrome (CdLS) in depth by examining a large number of variables with varying measurement levels. Virtually the only suitable multivariate technique for this is categorical…

Background: Tuberous sclerosis (TSC) is a multi-system disorder caused by heterozygous mutations in the "TSC1" or "TSC2" gene and is often associated with neuropsychiatric symptoms, including intellectual disability, specific neuropsychological deficits, autism, other behavioural disorders and epilepsy. Method: Here, we review evidence from animal…

Stuttering interferes with a person's ability to speak fluently. It involves the repetition; prolongation; or blockage of sounds, syllables, or words. When a child stutters, he may hesitate to raise his hand in class, read aloud, or talk with other children in the class. Stuttering usually begins between the ages of two and four. While there is no…

This article describes a new approach to teaching bioinformatics using "Arabidopsis" genetic sequences. Several open-ended and inquiry-based laboratory exercises have been designed to help students grasp key concepts and gain practical skills in bioinformatics, using "Arabidopsis" leucine-rich repeat receptor-like kinase (LRR…

This commentary brings additional theoretical perspectives to bear on data and findings presented by Anniken Furberg and Hans Christian Arnseth in their paper on students' meaning making in genetics in collaborative learning activities. The theoretical perspectives converge on the importance of maximizing students' learning in genetics. The…

Background: The behavioural phenotypes of Prader-Willi (PWS) and Fragile-X (FraX) syndromes both comprise repetitive behaviours with differences between the profiles. In this study we investigated the context and antecedents to the repetitive behaviours and the association with other behavioural phenotypic characteristics in order to generate…

I present a laboratory procedure for illustrating transcription, post-transcriptional modification, gene conservation, and comparative genetics for use in undergraduate biology education. Students are individually assigned genes in a targeted biochemical pathway, for which they design and test polymerase chain reaction (PCR) primers. In this…

Background: Despite the evidence on anomalous attachment patterns, there has been a tendency to interpret most of these as reflecting differences in security/insecurity. Methods: Empirical research findings are reviewed in relation to attachment/insecurity as evident in both infancy and later childhood, disorganised attachment, inhibited…

Gilbert Gottlieb was an elegant experimentalist whose research was inspired in part by naturalistic observations of parent-offspring vocal-auditory interactions of waterfowl. Such observations are essential in identifying potential linear (obvious) as well as nonlinear (subtle) mechanisms underlying the development of species-typical behavior. His…

High-resolution karyotyping detects cytogenetic anomalies in 5-10% of cases of autism. Karyotyping, however, may fail to detect abnormalities of chromosome subtelomeres, which are gene rich regions prone to anomalies. We assessed whether panels of FISH probes targeted for subtelomeres could detect abnormalities beyond those identified by…

The author of this article believes that Ericsson and his associates continue to produce impressive research on talent and exceptional performances. He agrees that the objective of their featured article--"a general theoretical framework that establishes scientific criteria for acceptable evidence of superior reproducible performance, which any…

In this article, the author's comments are divided into two parts. In the first part, he tries to compose succinct formulations of the three challenges with which Professor Ericsson has confronted giftedness researchers. The following are Ericsson's three challenges of giftedness research: (1) Is there empirical evidence that reproducibly superior…

Genome-wide linkage and association analyses were conducted to identify genetic determinants of stuttering in a founder population in which 48 individuals affected with stuttering are connected in a single 232-person genealogy. A novel approach was devised to account for all necessary relationships to enable multipoint linkage analysis. Regions…