Since the identification of the FMR1 gene basic research has been focused on the molecular characterization of the FMR1 gene product, the fragile X mental retardation protein (FMRP). Recent developments in fragile X research have provided new insights and knowledge about the physiological function of FMRP in the cell and the nerve cell in…

Fragile X syndrome is the most common heritable form of mental retardation caused by loss-of-function mutations in the "FMR1" gene. The "FMR1" gene encodes an RNA-binding protein that associates with translating ribosomes and acts as a negative translational regulator. Recent work in "Drosophila melanogaster" has shown that the fly homolog of…

Proposes models for the evolution of the genetic code and translation mechanisms. Suggests that the translation process is so complex and precise that it must have evolved in many stages, and that the evolution of the code was influenced by the constraints imposed by the evolving translation mechanism. (EB)

Addresses issues related to genetic counseling and deafness. (Author/VWL)

Discusses genetics and its relevance to the lives of deaf people. Examines how the advances in genetics technologies have led to greater knowledge regarding the genetic causes of deafness and how this impacts the deaf community. (Author/VWL)

In the present study we confirm the previously reported high frequency of biochemical markers of mitochondrial dysfunction, namely hyperlactacidemia and increased lactate/pyruvate ratio, in a significant fraction of 210 autistic patients. We further examine the involvement of the mitochondrial aspartate/glutamate carrier gene ("SLC25A12") in…

This article undertakes a close rhetorical reading of the speeches given by Bill Clinton, Tony Blair, Francis Collins, and Craig Venter on June 26, 2000, at the White House ceremony announcing the completion of the Human Genome Project. Specifically, it looks at the metaphors used by each speaker to describe the activity of genomic scientists.…

In 1889, German biologist August Weissmann showed that mice whose tails are cut off do not produce short-tailed offspring. It was a step forward for science, but a step backward for civilization. Weissmann's discovery was good for science because, contrary to what many scientists had believed, acquired characteristics are not, of course,…

The ethics of the use of genetic screening and reproductive technologies to select against and for deafness is presented. It is argued that insofar as deafness is a disability it is ethical to act in such a way as to avoid the conception or birth of children with genetic or congenital deafness. The discovery and recognition of signing deaf…

Well-documented Romance-Germanic differences in the use of accent in speech to convey information-structure and focus cause problems for the assessment of prosodic skills in populations with clinical disorders. The strategies for assessing the ability to use lexical and contrastive accent in English and Spanish are reviewed, and studies in the…

As twenty-first century skills become a greater focus in K-12 education, an infusion of technology that meets the needs of today's students is paramount. This study looks at the design and creation of a Multiplayer Educational Gaming Application (MEGA) for high school biology students. The quasi-experimental, qualitative design assessed the…

Talent identification and development processes are important components of many dance programmes, yet talent is notoriously difficult to define and its identification may rely on intuitive judgements. Taking a systematic approach to the study of dance talent could enable researchers and educators to better determine what talent actually "is," the…

In this monograph, the authors have brought the findings of the English and Romanian Adoptee (ERA) study up to age 15 years and, in so doing, have focused especially on the question of whether there are deprivation-specific psychological patterns (DSPs) that differ meaningfully from other forms of psychopathology. For this purpose, their main…

Gilbert Gottlieb's theory of probabilistic epigenesis is a fertile ground for further theoretical construction in developmental science. It fills the gap in the domineering empiricism and honoring of inductive generalization that dominates psychology in the beginning of the 21st century, by offering a basic deductive framework for guiding the…