In this paper, we present a concise and technique-heavy route to the synthesis of dimedone for a second-year organic chemistry curriculum. Our preparation of dimedone guides students through a Michael addition followed by a Dieckmann cyclization, basic ester hydrolysis, and thermal decarboxylation, while allowing time for mechanistic discussion…

The synthesis of a [2]rotaxane through three- or five-component coupling reactions has been adapted to an organic chemistry experiment for upper-division students. The experimental procedure addresses the search for the most favorable reaction conditions for the synthesis of the interlocked compound, which is obtained in a yield of up to 71%.…

Metabolic Control Analysis (MCA) is a systems biology approach that measures the control of a metabolic step on the overall flux of a metabolic pathway. In undergraduate courses in biochemistry, learning of MCA can be encouraged by experimental activities demonstrating practical applications of the MCA theory. In this work, we present a laboratory…

An understanding of basic organic chemical reactivity is key for many biosciences students. The reactivities of different carbonyl groups affect their function in many biomolecules. A practical class, the two-step synthesis of paracetamol, has been devised to illustrate the electrophilic reactivities of carbonyls, which was covered in the…

Calorimetry is a central concept in the first semester general chemistry curriculum, and constant pressure (coffee-cup) calorimetry is a common experiment in the laboratory. However, constant volume (bomb) calorimetry is traditionally reserved for the physical chemistry laboratory. This article describes the advantages of incorporating bomb…

This publication presents a series of experiments in the field of nanomedicine for high school chemistry education and student laboratories, developed as a collaborative project between chemistry didactics and chemical research. In this context, polymeric nanocarriers represent a promising approach for drug delivery, acting as "smart…

In the light of own measurements on a Faraday generator, the well-known theories concerning Unipolar Induction and the Faraday paradox seem to be problematic. On the other hand, all results obtained, and all other processes described as a paradox in connection with the Faraday generator can be explained without contradiction based on the theory of…

Two balls on an incline can remain at rest if friction between the balls prevents them rolling down the incline. Results with various balls are presented to show how ball mass, diameter and friction affects the outcome. A stack of four identical balls is also examined.

We adapted a classical asymmetric Michael addition for a 1 day experimental session (6-8 h) for third- or fourth-year undergraduate students. The experiment contains three steps: synthesis of a chiral Lewis acid, LiAl((S)-BINOL)[subscript 2], then its use as a catalyst in the Michael addition of diethyl malonate on cyclopentenone, followed by…

A standard physics experiment for students is to measure the terminal velocity of an object in air or in glycerine. A more difficult challenge is to measure the terminal velocity in water since the depth of the water needs to be large or the object needs to be dropped in the water at a speed close to its terminal velocity. Results obtained by…

One step of the published mechanism of the hydrogen peroxide iodine-clock reaction is called into question by the result of an experimental attempt (predicated on that mechanism) to integrate that reaction into the elephant's toothpaste demonstration to reveal and control its iodine side product. Under conditions that were a hybrid of those…

Carbonated beverages have long provided chemical educators and other teachers of science with an easy-to-obtain system that connects to several physicochemical concepts. For example, many educators have devised experiments to determine the pressure of CO[subscript 2] contained in commercial carbonated beverages, but the role of temperature in such…

In this paper we consider the well-known experiment with the 'heavy' newspaper that breaks a stick that it is laid on. Using several appropriate control experiments we show that the currently invoked explanation using atmospheric pressure cannot be correct. We perform a theoretical analysis and propose a new explanation based on the rotational…

This paper introduces a safe, interesting, convenient, and low-cost experiment. The products of galvanic cells and electrolytic cells are compressed into specimens that are placed on a slide to stretch the metal dendrites in one plane and ensure they are not easily destroyed by external factors. The details and growth process of the metal…

A previous journal article established that a hanging Slinky's restoring force is due only to the coils between the support and the Slinky's center of mass (hereafter COM). Correspondingly, it is expected the Slinky's elastic potential energy (hereafter EPE) is associated with only those coils; however, there is no confirming experimental…