In this laboratory experiment, students learn how to use ESI to accelerate chemical synthesis and to couple it with on-line mass spectrometry for structural analysis. The Hantzsch synthesis of symmetric 1,4-dihydropyridines is a classic example of a one-pot reaction in which multiple intermediates can serve to indicate the progress of the reaction…

A procedure to improve the greenness of a synthesis, without performing laboratory work, using alternative protocols available in the literature is presented. The greenness evaluation involves the separate assessment of the different steps described in the available protocols--reaction, isolation, and purification--as well as the global process,…

At present, small molecule drug design follows a retrospective path when considering what analogs are to be made around a current hit or lead molecule with the focus often on identifying a compound with higher intrinsic potency. What this approach overlooks is the simultaneous need to also improve the physicochemical (PC) and pharmacokinetic (PK)…

This research follows the previous study examining the effect of chemistry education on students' perception and understanding to the nature of chemistry (NoC) as well as their attitudes towards it as a school subject. Grade 9 students (N = 282) at the end of their compulsory schooling were given a set of open-ended questions focused on their…

The Periodic Table of the Elements (PTE) is arguably one of the most central topics in chemistry. This article provides a critical review of current teaching practices of the PTE to high-school students and undergraduate university students. It also provides a new teaching model, the "periodic universe", for understanding of the PTE…

Background: Calls for science education reform have been made for decades in the USA. The recent call to produce one million new science, technology, engineering, and math (STEM) graduates over 10 years highlights the need to employ evidence-based instructional practices (EBIPs) in undergraduate STEM classes to create engaging and effective…

The tutorials of a second-year undergraduate organic chemistry course have been modified to include a retrosynthetic exercise in conjunction with a Molecule of the Week (MoW) challenge. In contrast to the original tutorial assignments in the course, which primarily focused on completing simple reaction roadmaps, the new tutorials place a heavier…

The aim of the present investigation was to analyse the role of academic self-efficacy and approaches to learning in general and in Physics and Chemistry academic achievements. The sample comprised 507 secondary school students of two Spanish schools and the study was conducted in the context of a Physics and Chemistry subject. Structural equation…

In this study, a set of hybrid images was designed as a new and up-to-date unexamined type of external visual representations in the chemistry classroom. One challenging teaching theme was chosen ("Amino acids and proteins"), and the hybrid images were used among novices--primary school students. For the purpose of the study, two groups…

Lab activities typically involve phenomena that are invisible to the naked eye. For example, in thermodynamics transfer of heat and temperature changes are perceived by the sense of touch or indirectly observed by the use of thermometers. New tools can be introduced to increase the opportunities for talking science. In this paper, we explore…

The purpose of this study was to investigate the effect of the case-based learning (CBL) method used in "biochemical oxygen demand (BOD)," which is a topic taught in the environmental chemistry course, at Dokuz Eylul University, on the academic achievement and opinions of students. The research had a quasi-experimental design and the…

A low-cost turbidimeter, colorimeter, and nephelometer (TCN) multipurpose instrument applicable for undergraduate, graduate, and research laboratories is demonstrated within this work. The instrument relies on simple and robust electronics while using a PC sound card as an analog-to-digital converter. The performance of the instrument was…

Creating instructional activities and assessments that align with expected learning outcomes can improve student learning. Communicating learning expectations to students may lead to better student performance and an increase in student perceptions of the fairness of the assessment tools. One tool for communicating learning outcomes is the…

A service-learning course at a midsized Midwestern research university was modified over a period of six years to integrate best-practice pedagogies that have been shown to increase civic engagement by students. Best-practice pedagogies included regular interaction with community partner(s), significant time spent on the service activity, and…

Stoichiometry, which deals with the quantitative aspects of Chemistry, is a topic students find challenging and which teachers struggle to teach. South African students' performance in stoichiometry in the final matriculation examinations has led to calls for the topic to be taught better and highlighted the need for teacher professional…