Core vocabulary is defined as "lexical items that are accepted as being central and indispensable to language use" (Bell, 2012, p. 1). Use of core vocabulary is common amongst professionals who teach augmentative and alternative communication (AAC) to individuals with disabilities. Although the use of AAC is often classified as an evidence-based practice (EBP) (Steinbrenner et al., 2020; Wong et al., "Journal of Autism and Developmental Disorders," 45(7), 1951-1966, 2015) an analysis of the relevant intervention procedures as well as the vocabulary used is often missing from syntheses of the literature. Therefore, a systematic review was conducted to determine the quality and strength of the evidence for AAC interventions that use core vocabulary. A systematic database search and a subsequent screening process resulted in a total of 10 peer-reviewed studies that involved an AAC intervention that used core vocabulary. Each study's outcomes were then categorized as positive, mixed, or negative and a quality review was performed using the Council for Exceptional Children's (CEC) standards for evidence-based practices (Cook et al., "Teaching Exceptional Children," 46(6), 206-212, 2015a; "Remedial and Special Education," 36, 220-234, 2015b). Overall, the results suggest a lack of strong evidence in favor of AAC interventions that use core vocabulary. The results are discussed in the context of general suggestions for vocabulary selection and teaching practices for AAC systems.