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Direct linkBassiri, Eby A. – Biochemistry and Molecular Biology Education, 2011
A five-session laboratory project was designed to familiarize or increase the laboratory proficiency of biology students and others with techniques and instruments commonly used in molecular biology research laboratories and industries. In this project, the EZ-Tn5 transposon is used to generate and screen a large number of cells transformed with…
Descriptors: Laboratory Procedures, Molecular Biology, Laboratory Experiments, Science Laboratories
Esernio-Jenssen, Debra; Barnes, Marilyn – Journal of Child Sexual Abuse, 2011
The American Academy of Pediatrics recommends that site-specific cultures be obtained, when indicated, for sexually victimized children. Nucleic acid amplification testing is a highly sensitive and specific methodology for identifying sexually transmitted infections. Nucleic acid amplification tests are also less invasive than culture, and this…
Descriptors: Sexual Abuse, Child Abuse, Testing, Sexually Transmitted Diseases
Schultheis, Patrick J.; Bowling, Bethany V. – Biochemistry and Molecular Biology Education, 2011
Recent experimental evidence indicates that the ability of adults to tolerate milk, cheese, and other lactose-containing dairy products is an autosomal dominant trait that co-evolved with dairy farming in Central Europe about 7,500 years ago. Among persons of European descent, this trait is strongly associated with a C to T substitution at a…
Descriptors: Genetics, Molecular Biology, Foreign Countries, Teaching Methods
DeSantis, Kara A.; Reinking, Jeffrey L. – Biochemistry and Molecular Biology Education, 2011
This laboratory exercise is an inquiry-based investigation developed around the core experiment where students, working alone or in groups, each purify and analyze their own prescreened colored proteins using immobilized metal affinity chromatography (IMAC). Here, we present reagents and protocols that allow 12 different proteins to be purified in…
Descriptors: Molecular Biology, Biochemistry, Laboratory Experiments, Inquiry
Nieto, Rebeca Garcia; Castellanos, F. Xavier – Journal of Clinical Child and Adolescent Psychology, 2011
Despite the nosological distinction between bipolar disorder and schizophrenia, there is increasing evidence that these conditions share phenomenological characteristics. To examine the similarities in their patterns of cognitive impairment, we conducted a meta-analysis from 12 studies of Early Onset Schizophrenia (EOS) and 12 studies of Pediatric…
Descriptors: Schizophrenia, Verbal Learning, Patients, Cognitive Processes
Download full textBartlett, Joan C.; Ishimura, Yusuke; Kloda, Lorie A. – Information Research: An International Electronic Journal, 2011
Purpose: The objective was to identify and understand the factors involved in scientists' selection of preferred bioinformatics tools, such as databases of gene or protein sequence information (e.g., GenBank) or programs that manipulate and analyse biological data (e.g., BLAST). Methods: Eight scientists maintained research diaries for a two-week…
Descriptors: Scientists, Criteria, Decision Making, Research
Ozgen, Heval; Hellemann, Gerhard S.; Stellato, Rebecca K.; Lahuis, Bertine; van Daalen, Emma; Staal, Wouter G.; Rozendal, Marije; Hennekam, Raoul C.; Beemer, Frits A.; van Engeland, Herman – Journal of Autism and Developmental Disorders, 2011
This study was designed to examine morphological features in a large group of children with autism spectrum disorder versus normal controls. Amongst 421 patients and 1,007 controls, 224 matched pairs were created. Prevalence rates and odds ratios were analyzed by conditional regression analysis, McNemar test or paired t-test matched pairs.…
Descriptors: Control Groups, Autism, Pervasive Developmental Disorders, Children
Flynn-Charlebois, Amber; Burns, Jamie; Chapelliquen, Stephanie; Sanmartino, Holly – Journal of Chemical Education, 2011
A low-cost biochemistry experiment is described that demonstrates current techniques in the use of catalytic DNA molecules and introduces a nonradioactive, nonfluorescent, inexpensive, fast, and safe method for monitoring these nucleic acid reactions. The laboratory involves the exploration of the 10-23 DNA enzyme as it cleaves a specific RNA…
Descriptors: Undergraduate Students, Genetics, Science Instruction, Science Laboratories
Butler, Jill V.; Whittington, Joyce E.; Holland, Anthony J.; McAllister, Catherine J.; Goldstone, Anthony P – Developmental Medicine & Child Neurology, 2010
Aim: Prader-Willi syndrome (PWS) is a genetic disorder historically characterized by two phenotypic stages. The early phenotype in infants is associated with hypotonia, poor suck, and failure to thrive. In later childhood, PWS is associated with intellectual disability, hyperphagia, as well as growth and sex hormone deficiency. Little is known…
Descriptors: Genetic Disorders, Obesity, Body Composition, Mental Retardation
Nijmeijer, Judith S.; Arias-Vasquez, Alejandro; Rommelse, Nanda N. J.; Altink, Marieke E.; Anney, Richard J. L.; Asherson, Philip; Banaschewski, Tobias; Buschgens, Cathelijne J. M.; Fliers, Ellen A.; Gill, Michael; Minderaa, Ruud B.; Poustka, Luise; Sergeant, Joseph A.; Buitelaar, Jan K.; Franke, Barbara; Ebstein, Richard P.; Miranda, Ana; Mulas, Fernando; Oades, Robert D.; Roeyers, Herbert; Rothenberger, Aribert; Sonuga-Barke, Edmund J. S.; Steinhausen, Hans-Christoph; Faraone, Stephen V.; Hartman, Catharina A.; Hoekstra, Pieter J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: The genetic basis for autism spectrum disorder (ASD) symptoms in children with attention-deficit/hyperactivity disorder (ADHD) was addressed using a genome-wide linkage approach. Method: Participants of the International Multi-Center ADHD Genetics study comprising 1,143 probands with ADHD and 1,453 siblings were analyzed. The total and…
Descriptors: Attention Deficit Hyperactivity Disorder, Siblings, Autism, Genetics
Newbury, H. John – School Science Review, 2010
One of the striking characteristics of fundamental biological processes, such as genetic inheritance, development and primary metabolism, is the limited amount of variation in the molecules involved. Natural selective pressures act strongly on these core processes and individuals carrying mutations and producing slightly sub-optimal versions of…
Descriptors: Biochemistry, Molecular Biology, Molecular Structure, Cytology
Haresnape, Janet M. – School Science Review, 2010
These activities, prepared for key stage 5 students (ages 16-18) and also suitable for key stage 4 (ages 14-16), show that physical appearance is not necessarily the best way to classify mammals. DNA structure is examined to show how similarities and differences between DNA sequences of mammals can be used to establish evolutionary relationships.…
Descriptors: Evolution, Animals, Science Activities, Secondary School Science
Perovic, Alexandra; Wexler, Kenneth – Journal of Speech, Language, and Hearing Research, 2010
Purpose: To experimentally investigate knowledge of passives of actional ("hold") and psychological ("love") verbs in children with Williams syndrome (WS). Passives are usually reported to be in line with mental age in WS. However, studies usually focus on passives of actional verbs only. Method: Twenty-six children with WS, ages 6-16, and 3…
Descriptors: Genetic Disorders, Verbs, Syntax, Children
Ardiel, Evan L.; Rankin, Catharine H. – Learning & Memory, 2010
This article reviews the literature on learning and memory in the soil-dwelling nematode "Caenorhabditis elegans." Paradigms include nonassociative learning, associative learning, and imprinting, as worms have been shown to habituate to mechanical and chemical stimuli, as well as learn the smells, tastes, temperatures, and oxygen levels that…
Descriptors: Learning, Memory, Animals, Literature Reviews
Zars, Troy – Learning & Memory, 2010
In a dynamic environment, there is an adaptive value in the ability of animals to acquire and express memories. That both simple and complex animals can learn is therefore not surprising. How animals have solved this problem genetically and anatomically probably lies somewhere in a range between a single molecular/anatomical mechanism that applies…
Descriptors: Animals, Anatomy, Short Term Memory, Genetics
