This practice brief draws upon recent recommendations regarding English learners (ELs) and evidence-based instructional practices for teachers relevant for learning in science and engineering in grades kindergarten through 12 (K-12). The two documents that inform this brief are, "English Learners in STEM Subjects: Transforming Classrooms, Schools, and Lives. Consensus Study Report" and "Using Educational Technology -- 21st Century Supports for English Learners. Educator Toolkit." Five key educator practices are featured: (1) Embrace asset beliefs that position and support ELs as full participants in disciplinary learning; (2) Engage ELs in science and engineering practices; (3) Engage ELs in meaningful interactions with other students and teachers; (4) Provide scaffolding as a way of supporting students' engagement and comprehension of challenging content; and (5) Provide an explicit focus on how language functions in these disciplines. For each key practice, this brief describes and references the research, illustrates the practice in action, and offers additional tools and resources.