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ERIC Number: EJ1274816
Record Type: Journal
Publication Date: 2020-Nov
Pages: 7
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-1759-2879
EISSN: N/A
Available Date: N/A
Zero-Cell Corrections in Random-Effects Meta-Analyses
Weber, Frank; Knapp, Guido; Ickstadt, Katja; Kundt, Günther; Glass, Änne
Research Synthesis Methods, v11 n6 p913-919 Nov 2020
The standard estimator for the log odds ratio (the unconditional maximum likelihood estimator) and the delta-method estimator for its standard error are not defined if the corresponding 2 x 2 table contains at least one "zero cell". This is also an issue when estimating the overall log odds ratio in a meta-analysis. It is well known that correcting for zero cells by adding a small increment should be avoided. Nevertheless, these zero-cell corrections continue to be used. With this Brief Method Note, we want to warn of a particularly bad zero-cell correction. For this, we conduct a simulation study comparing the following two zero-cell corrections under the ordinary random-effects model: (a) adding 1/2 to all cells of all the individual studies' 2 x 2 tables independently of any zero-cell occurrences and (b) adding 1/2 to all cells of only those 2 x 2 tables containing at least one zero cell. The main finding is that correction (a) performs worse than correction (b). Thus, we strongly discourage the use of correction (a).
Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A
Author Affiliations: N/A